What is the difference between osteoarthritis and rheumatoid arthritis?
They share a name and almost nothing else. Osteoarthritis is a problem of the joint structure; rheumatoid arthritis is a disease of the immune system that happens to attack joints — and they are treated in completely different ways.
Osteoarthritis involves the breakdown of cartilage and changes to the underlying bone. It is by far the more common, associated with age, previous injury, joint loading and genetics. It is not simply "wear and tear" — that framing is increasingly rejected, because the joint is actively remodelling rather than passively wearing out, and because exercise improves it rather than accelerating it.
Its pattern: usually asymmetric; affecting weight-bearing joints, hands and the spine; pain worse with activity and better with rest; stiffness after inactivity that eases within around 30 minutes; and gradual onset over years.
Rheumatoid arthritis is an autoimmune condition in which the immune system attacks the synovial lining of joints, causing inflammation that can destroy the joint and affect other organs including lungs, eyes, skin and blood vessels.
Its pattern: typically symmetric, affecting the same joints on both sides; small joints of hands and feet first; morning stiffness lasting over an hour; fatigue and feeling generally unwell; and it can begin at any age, including childhood.
Why the distinction is urgent. Rheumatoid arthritis causes irreversible joint damage, and there is a well-established treatment window in which disease-modifying drugs substantially change the long-term outcome. Delay costs joints permanently, which is why persistent symmetrical joint swelling with prolonged morning stiffness warrants prompt assessment rather than watchful waiting.
How they are treated:
Osteoarthritis — exercise and strengthening, which is the single most effective intervention and is consistently under-prescribed; weight management where relevant; pain relief; physiotherapy; and joint replacement where function is severely limited.
Rheumatoid arthritis — disease-modifying drugs and biologics suppressing the immune process, alongside exercise and specialist monitoring.
Other types exist, including gout, psoriatic and reactive arthritis, which are different again.
General information, not medical advice.