What is the difference between a food allergy and an intolerance?
An allergy involves the immune system. An intolerance does not. That distinction determines severity, mechanism, testing and management, and confusing the two is both common and occasionally dangerous.
Food allergy. The immune system misidentifies a food protein as a threat and mounts a response, typically involving IgE antibodies. Reactions are:
Fast — usually within minutes to two hours.
Dose-independent in principle — trace amounts can trigger a severe reaction, which is why "may contain" warnings exist.
Potentially life-threatening. Anaphylaxis involves breathing difficulty, swelling of the throat and tongue, a drop in blood pressure and collapse. It is a medical emergency requiring adrenaline (epinephrine) and an ambulance.
Other symptoms: hives, swelling, vomiting, wheezing.
Common allergens: peanuts, tree nuts, milk, egg, fish, shellfish, soy, wheat, sesame.
Food intolerance. A non-immune reaction, usually digestive, typically caused by an enzyme deficiency or a chemical sensitivity.
Slower — often hours later.
Dose-dependent. Many people with lactose intolerance tolerate small amounts without difficulty, which is never true of an allergy.
Unpleasant but not life-threatening — bloating, cramps, diarrhoea, headaches.
Common examples: lactose intolerance, from reduced lactase enzyme; histamine intolerance; sensitivity to sulphites or caffeine; and FODMAP sensitivity, central to IBS.
Coeliac disease is neither — it is an autoimmune condition in which gluten triggers the immune system to damage the small intestine lining. It is not an allergy and not an intolerance, it causes long-term harm rather than immediate symptoms, and it requires strict lifelong avoidance. Testing must be done while still eating gluten, which is why self-diagnosis by elimination causes problems.
On testing: allergy is diagnosed by clinical history plus skin prick or specific IgE blood tests. IgG food intolerance tests sold commercially are not supported by professional allergy bodies.