Question

What do the kidneys do, and what is dialysis?

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The kidneys do far more than make urine. They are continuous chemical regulators, and dialysis replaces only part of what they do — which is why it is a treatment rather than a cure.

What healthy kidneys do:

Filter blood, removing waste products of metabolism, drugs and excess substances. The whole blood volume passes through them many times a day.

Control fluid balance, deciding how much water to retain or excrete — the main reason kidney failure causes swelling and breathlessness.

Regulate electrolytes — sodium, potassium, calcium, phosphate. Potassium control is the acutely dangerous one, since high levels can stop the heart.

Maintain acid-base balance.

Control blood pressure, through fluid volume and the renin-angiotensin system — which is why kidney disease and hypertension drive each other in both directions.

Produce erythropoietin, the hormone telling bone marrow to make red blood cells — hence the anaemia of kidney disease.

Activate vitamin D, which is why kidney failure damages bone.

What dialysis does. It substitutes the filtration and fluid-removal functions only. Blood is exposed to a special fluid across a semi-permeable membrane; wastes and excess electrolytes move across by diffusion, and fluid is removed by pressure.

Haemodialysis circulates blood through an external machine, typically three times a week for around four hours, in a unit or at home. It requires vascular access — usually a fistula created surgically months in advance.

Peritoneal dialysis uses the lining of the abdomen as the membrane, with fluid exchanged several times daily or overnight at home. More flexible, with infection risk as the main complication.

Why it is not equivalent to a kidney. Dialysis is intermittent where kidneys work continuously, so levels swing between sessions; and it replaces none of the hormonal functions, which must be supplied separately. Diet and fluid restriction remain necessary.

Transplantation gives better outcomes and quality of life for suitable candidates, which is why dialysis is often a bridge rather than a destination.

General information, not medical advice.

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