Question

Who was Henrietta Lacks?

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A Black American woman whose cancer cells, taken without her knowledge or consent in 1951, became the first human cell line to survive and multiply indefinitely in culture — and which have since underpinned an enormous proportion of modern biomedical research.

What happened. Henrietta Lacks, a tobacco farmer and mother of five, was treated for cervical cancer at Johns Hopkins Hospital, one of the few hospitals then treating Black patients. During treatment, a sample of her tumour was taken and passed to a researcher without her being told or asked. This was not unlawful at the time, and was common practice — which is part of the point.

She died later that year, aged 31, and was buried in an unmarked grave.

Why the cells mattered so much. Human cells had consistently died in culture. Hers — designated HeLa — did not. They divided indefinitely, robustly and rapidly, giving researchers for the first time a reliable, reproducible supply of living human cells.

What they were used for: developing and testing the polio vaccine; work on cancer, HIV and the human papillomavirus; the effects of radiation; gene mapping; in vitro fertilisation techniques; and research conducted in space. HeLa cells have featured in many tens of thousands of scientific papers and are still in daily use.

What happened to the family. They were not told for more than twenty years. When they learned, they discovered that cells derived from their mother were being bought and sold worldwide while the family could not afford healthcare. In the 1970s researchers approached them for blood samples without explaining why. Her genome was later published without consent, then withdrawn.

What changed because of it. The case became central to debates on informed consent, tissue ownership and racial inequity in medicine. An agreement was eventually reached giving family members a role in approving access to the HeLa genome, and settlements with companies profiting from the cells have followed.

Her name is now attached to institutes, buildings and awards.

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