What is DVT on long flights, and does anything actually prevent it?
Deep vein thrombosis is a blood clot forming in a deep vein, usually in the leg. Long-haul travel raises the risk modestly, and the mechanism is better understood than the folklore around it suggests.
Why travel raises the risk. Prolonged immobility is the main factor: the calf muscles act as a pump returning blood from the legs, and sitting still removes that pump, so blood pools and flows more slowly. Cramped seating position and pressure behind the knee add to it. Cabin pressure and low humidity contribute little, despite the popular "economy class syndrome" framing — the risk is about sitting still, and applies equally to long car and train journeys.
How large the risk actually is. For a healthy person on a single long flight it is very small in absolute terms, rising with flight duration and becoming measurable beyond roughly four hours. Risk rises with the number of flights in a short period.
Who is genuinely at higher risk: previous DVT or pulmonary embolism, known clotting disorders, recent major surgery — particularly of the hip, knee or abdomen — active cancer, pregnancy and the period after birth, combined hormonal contraception or HRT, obesity, significantly reduced mobility, and older age.
What actually helps:
Move. Walk when it is safe to do so, and do calf exercises in the seat — flexing and pointing the feet activates the muscle pump and is the single most useful thing.
Stay hydrated and moderate alcohol, which mainly helps by keeping you moving and avoiding dehydration.
Graduated compression stockings, which have reasonable evidence for reducing symptomless clots on long flights and are worth considering for higher-risk travellers. Fit matters, and badly fitted ones can do harm.
Aisle seats, which make moving easier.
Anticoagulation only where medically advised. Aspirin is not recommended for travel thrombosis prevention.
Symptoms to act on: calf pain, swelling, warmth or redness in one leg; and — urgently — breathlessness, chest pain or coughing blood, which can indicate a clot reaching the lungs. Symptoms can appear up to several weeks after travel, and mentioning recent flights to a doctor matters.
General information, not medical advice.