What changes in a mole should you actually worry about?
Change itself is the signal — a mole that is different from how it was, or different from your other moles, matters more than any single feature in isolation.
The ABCDE checklist, which is the standard framing:
Asymmetry — one half unlike the other.
Border — irregular, blurred, notched or ragged rather than smooth.
Colour — more than one colour, uneven, or shades of brown, black, red, white or blue within one lesion.
Diameter — larger than about 6 mm, though melanoma can be smaller and this is the weakest criterion.
Evolving — changing in size, shape, colour, or becoming raised. This is the most important letter, and change is the single most useful sign.
The other signs worth knowing:
The ugly duckling sign. Most people's moles resemble each other. A lesion that stands out as different from your others is suspicious even if it passes ABCDE — and this catches cases the checklist misses.
Itching, bleeding, crusting or a sore that does not heal, particularly a lesion that bleeds on minor contact.
A new mole appearing after about 30, when most moles have already developed.
A dark streak under a nail that is not from injury, which can indicate a less common melanoma type.
Changes on soles, palms, under nails and in less exposed sites, which are easily missed and are more common presentations in people with darker skin — where melanoma is rarer but more frequently diagnosed late.
Who is at higher risk: fair skin that burns easily, many moles, atypical moles, previous skin cancer, family history, history of sunburn particularly in childhood, sunbed use, and immunosuppression.
The other skin cancers are more common than melanoma and look different — basal cell carcinoma as a pearly or waxy bump or a sore that heals and returns, and squamous cell as a firm scaly or crusted lump.
What to do: photograph anything you are unsure about with a ruler for scale; see a GP rather than waiting; and do not be reassured by a lesion being painless, since most are.
General information, not medical advice.